A tornado warning was issued by the National Weather Service on Saturday at 7:50 p.m. in effect until 8:30 p.m. for Calhoun, Clay, Cleburne and Talladega counties.

Jeff Smitherman, the director of an Alabama emergency management agency, joins ABC News live to discuss the high-risk alert for potential tornado outbreaks in Alabama and Mississippi.

Alabama was bracing for Round 2 of severe weather on Saturday. Round 1 started early this morning and prompted two tornado warnings and multiple severe thunderstorm warnings but no damage has been reported so far.

As many as 150 million people in the U.S. face a potential severe weather outbreak in the coming days. Storms will likely reach the Tampa Bay area late Sunday, bringing a marginal risk of severe weather to part of the region.

Forecasts have placed a large portion of Alabama under the highest risk of severe weather ahead of an expected outbreak on Saturday. About noon on Friday the National Weather Service's storm prediction center placed a large part of central Alabama under a level five risk of severe weather.

Millions of Americans across the country are on alert for a severe weather outbreak as violent, long-track tornadoes with damaging winds of up to 80 mph and large hail are expected across the Midwest and South with the cross-country storm moving east.

About 47 million people faced an enhanced to moderate severe storm threat from Madison, Wisconsin, to Birmingham, Alabama.

Thousands of power outages were reported Saturday as a deadly severe weather outbreak moved across the Midwest and South.