In the first game No. 16 St. Francis (PA) will square off with No. 16 Alabama State, with a trip to Kentucky to take on the top overall seed Auburn on the line. In the second game, No. 11 North Carolina — a surprising inclusion in the tournament — takes on No.

Now, SportsLine's advanced computer model has simulated the entire 2025 NCAA Tournament 10,000 times to come up with the perfect 2025 NCAA Tournament bracket and find out which teams will pull off the biggest upsets. You shouldn't even think about making a pick without seeing what their model has to say.

Madness teams could pull off upsets in the first round? Here's eight bracket-buster predictions for Round of 64 NCAA Tournament bracket.